Rajiv Jain

Biography

Before coming to Calgary, I completed my PhD studies at the University of Western Ontario in London Ontario focusing primarily on basic B cell biology. My PhD work did not have a prominent translatable component which is why I decided to come out to Calgary and study B cells in the context of MS. Outside of the lab I am usually reading a book, cooking, or taking care of an extraordinarily handsome cat.

Publications

Jain RW, Parham KA, Tesfagiorgis Y, Craig HC, Romanchik E, and Kerfoot SM. Autoreactive, low-affinity T cells preferentially drive differentiation of short-lived memory B cells at the expense of germinal center maintenance. Cell Reports. 25(12):3342-3355.e5. 2018. https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+30566861

Whittaker Hawkins RF, Patenaude A, Dumas A, Jain R, Tesfagiorgis Y, Kerfoot S, Matsui T, Gunzer M, Poubelle PE, Larochelle C, Pelletier M, and Vallières L. ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis. Journal of Clinical Investigation Insight. 2(23): e96882. 2017.https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+29212956

Tesfagiorgis Y, Zhu SL, Jain R, and Kerfoot S. Activated B Cells Participating in the Anti-Myelin Response Are Excluded from the Inflamed Central Nervous System in a Model of Autoimmunity that Allows for B Cell Recognition of Autoantigen. Journal of Immunology. 199(2), 449-57, 2017.https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+28584006

Dang AK, Tesfagiorgis Y, Jain RW, Craig HC, and Kerfoot S. Meningeal infiltration of the spinal cord by non-classically activated B cells is associated with chronic disease course in a spontaneous B cell-dependent model of CNS autoimmune disease. Frontiers in Immunology. 470(6), doi: 10.3389/fimmu.2015.00470, 2015.https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+26441975

Dang AK, Jain RW, Craig HC, and Kerfoot S. B cell recognition of myelin oligodendrocyte glycoprotein autoantigen depends on immunization with protein rather than short peptide, while B cell invasion of the CNS in autoimmunity does not. Journal of Neuroimmunology. 278, 73-84, 2015.https://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+25595255