Reza Mirzaei

Biography

I obtained my PhD in Immunology from Tehran University in 2015 where I tried to boost anti-cancer T cell responses by dendritic cells. I joined the Yong lab as a postdoc in late 2015 where my project focuses on dissecting the mechanisms of T cell exhaustion in glioblastoma patients. For fun, I like playing squash and tennis when I am not in the lab.

Publications

Mirzaei R, Sarkar S, Dzikowski L, Rawji KS, Khan L, Faissner A, Bose P, Yong VW. Brain tumor-initiating cells export tenascin-C associated with exosomes to suppress T cell activity. Oncoimmunology. 2018 Aug 6;7(10):e1478647.https://www.ncbi.nlm.nih.gov/pubmed/30288344

Sarkar S, Mirzaei R, Zemp FJ, Wei W, Senger DL, Robbins SM, Yong VW. Activation of NOTCH Signaling by Tenascin-C Promotes Growth of Human Brain Tumor-Initiating Cells.Cancer Res. 2017 Jun 15;77(12):3231-3243.https://www.ncbi.nlm.nih.gov/pubmed/28416488

Mirzaei R, Sarkar S, Yong VW. T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints.Trends Immunol. 2017 Feb;38(2):104-115.https://www.ncbi.nlm.nih.gov/pubmed/27964820

Mirzaei R, Saei A, Torkashvand F, Azarian B, Jalili A, Noorbakhsh F, Vaziri B, Hadjati J. Identification of proteins derived from Listeria monocytogenes inducing human dendritic cell maturation. Tumour Biol. 2016 Aug;37(8):10893-907. https://www.ncbi.nlm.nih.gov/pubmed/26886282

Namdar A, Mirzaei R, Memarnejadian A, Boghosian R, Samadi M, Mirzaei HR, Farajifard H, Zavar M, Azadmanesh K, Elahi S, Noorbakhsh F, Rezaei A, Hadjati J. Prophylactic DNA vaccine targeting Foxp3+ regulatory T cells depletes myeloid-derived suppressor cells and improves anti-melanoma immune responses in a murine model. Cancer Immunol Immunother. 2018 Mar;67(3):367-379. https://www.ncbi.nlm.nih.gov/pubmed/29124314